Genetic risk factors for intracranial aneurysms: A meta-analysis in more than 116,000 individuals
نویسندگان
چکیده
منابع مشابه
Risk Factors for Growth of Intracranial Aneurysms: A Systematic Review and Meta-Analysis.
BACKGROUND AND PURPOSE Understanding risk factors for intracranial aneurysm growth is important for patient management. We performed a meta-analysis examining risk factors for intracranial aneurysm growth in longitudinal studies and examined the association between aneurysm growth and rupture. MATERIALS AND METHODS We searched the literature for longitudinal studies of patients with unrupture...
متن کاملShared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms
BACKGROUND Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS We performed a mega-analysis of 1000 Genomes Project-imputed genome-wide association study...
متن کاملRisk factors for multiple intracranial aneurysms.
BACKGROUND AND PURPOSE The presence of multiple intracranial aneurysms may be a sign of significant risk factors for aneurysm formation that differ from those factors that increase risk for aneurysm rupture. Only 2 studies concern independent risk factors for multiple aneurysms, and the results are in part controversial. This study was designed to identify independent risk factors for multiple ...
متن کاملGenetic factors involves in intracranial aneurysms – actualities
UNLABELLED Intracranial aneurysm (IA) is a common vascular disorder, which frequently leads to fatal vascular rupture leading to subarachnoid hemorrhage (SAH). Although various acquired risk factors associated with IAs have been identified, heritable conditions are associated with IAs formation but these syndromes account for less than 1% of all IAs in the population. Cerebral aneurysm disease ...
متن کاملAssociation of interleukin-6 -572G/C polymorphism with intracranial aneurysms risk: a meta-analysis
Intracranial aneurysm is mainly caused by the weakening of the arterial wall. The aim of the present article was to determine whether the interleukin-6 (IL-6) gene -572G/C polymorphism is correlated with intracranial aneurysms. The PubMed and Embase databases were retrieved to identify eligible IL-6 gene -572G/C polymorphism studies that examined the susceptibility to intracranial aneurysms ris...
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ژورنال
عنوان ژورنال: Neurology
سال: 2013
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e318295d751